期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 66, 期 9, 页码 843-846出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c18-00460
关键词
Ullmann C-O coupling reaction; D-alpha-tocopherol; 2,2-dialkyl chromane
资金
- Research Fund of Tokyo University of Science
The complete synthesis of D-alpha-tocopherol was achieved using our developed-Ullmann C-O coupling reaction as a key reaction. The synthesis of the core structure of D-alpha-tocopherol, which is a chiral chromane, has never been reported using intramolecular Ullmann C-O coupling reactions owing to the low reactivity of electron-rich iodoarenes with tertiary alcohols. Because the developed intramolecular C-O coupling reactions prefer electron-rich iodoarenes with tertiary alcohols, we successfully synthesized the chiral chromane core and achieved the total synthesis of D-alpha-tocopherol.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据