期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 62, 期 8, 页码 810-815出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c14-00351
关键词
3-styrylchromone; alpha-glucosidase inhibitor; antioxidant; structure-activity relationship
A series of 3-styrylchromone derivatives (4-20) were synthesized and the structure-activity relationships for alpha-glucosidase inhibition and antioxidant activities were analyzed. Among the synthesized compounds, compounds 15 and 20, which contain a catechol moiety, showed both potent 1,1-dipheny1-2-picrylhydrazyl (DPPH) free radical scavenging activity (15: EC50=17 mu m; 20: EC50=23 mu m) and alpha-glucosidase inhibitory activity (15: IC50=16 mu m; 20: IC50=10 mu m). Our data suggest that 3-styrylchromone derivatives are novel alpha-glucosidase inhibitors that have the potential to counteract diet-induced hyperglycemia in diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据