期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 61, 期 6, 页码 631-636出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c13-00040
关键词
quinolone derivative; antitumor; topoisomerase I; molecular docking
资金
- Natural Science Foundation of Zhejiang Province [Y2100908]
A novel series of quinolone derivatives (6a-n) were designed and synthesized, and their biological activities were evaluated as potential antitumor topoisomerase I (Top I) inhibitors. Among these compounds, 6j exhibited the most potent antitumor activities against multiple cancer cell lines. Docking simulation was performed to insert compound 6j into the crystal structure of DNA-Top I to determine the probable binding model.
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