期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 60, 期 3, 页码 385-390出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.60.385
关键词
xanthine derivative; monoamine oxidase B inhibition activity; substituent effect
资金
- Zhejiang Provincial Natural Science Foundation of China [Y2080697]
- Zhejiang Extremely Key Subject of Pharmacology and Biochemical Pharmaceutics
The design and synthesis of two series of 8-(substituted styrol-formamido)phenyl-xanthine derivatives are described. Their in vitro monoamine oxidase B (MAO-B) inhibition were tested and the effect of substituents on the N-7, phenyl and the substituted positions are discussed. It was observed that compound 9b displayed significant MAO-B inhibition activity and selectivity, fluorine substitution plays a key role in the selectivity of MAO-B inhibition, and the styrol-formamido group at position-3' may enhance the activity and selectivity of 8-phenyl-xanthine analogues. These results suggest that such compounds may be utilized for the development of new candidate MAO-B inhibitors for treatment of Parkinson's disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据