期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 60, 期 11, 页码 1437-1441出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c12-00616
关键词
butyrolactone; terretrione; Aspergillus terreus
资金
- National Science Foundation of China [20602042]
- National Technology Research and Development Program of China (863 Program) [2012AA092104]
- Institute of Materia Medica [2007CHX08]
- National Science AMP
- Technology Major Project 'Key New Drug Creation and Manufacturing,' China [2009ZX09301-003-4-1]
- Science AMP
- Technology Project of Guangdong Province [2011A080403020]
A new butyrolactone, 7 ''-hydroxybutyrolactone III (1) and three new cycloheptanetriones, terretrione A-C (2-4), together with five known compounds, butyrolactone I, cyclo(Leu-Pro), cyclo(Val-Pro), cyclo(Ile-Pro), cyclo(Phe-Pro), were isolated from mangrove-associated marine fungus Aspergillus terreus. The structures of these compounds were elucidated on the basis of physical data analysis (NMR, high resolution-electrospray ionization (HR-ESI)-MS), especially by 2D-NMR techniques. These compounds showed weak cytotoxicity in vitro against HCT-8, Bel-7402, RGC-823, A2780 cell lines.
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