期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 60, 期 1, 页码 144-149出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.60.144
关键词
Aconitum carmichaeli; cardioactive constituent; Fu Zi; N-deethylaconine; beiwutinine
资金
- National Natural and Science Foundation of China [81072550]
Bioassay-guided fractionation of an n-BuOH extract of the lateral roots of Aconitum carmichaeli DEUX. led to the isolation of 5 cardioactive C-19-diterpenoid alkaloids: N-deethylaconine (1), beiwutinine (2), hypaconine (3), mesaconine (4), and 15 alpha-hydroxyneoline (5). N-Deethylaconine and beiwutinine are new aconitine-type C-19-diterpenoid alkaloids. Hypaconine was isolated from this species for the first time. Among them, mesaconine, hypaconine, and beiwutinine showed the strongest cardiac actions on the isolated perfused bullfrog heart. Furthermore, mesaconine has protective effects, including improved inotropic effect and left ventricular diastolic function, on myocardial ischemia-reperfusion injury in rat at a dose of 10(-9) mol/L. However, mesaconine has almost no effect on heart rate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据