4.3 Article

Flavusides A and B, Antibacterial Cerebrosides from the Marine-Derived Fungus Aspergillus flavus

期刊

CHEMICAL & PHARMACEUTICAL BULLETIN
卷 59, 期 9, 页码 1174-1177

出版社

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.1174

关键词

flavuside; cerebroside; antibacterial activity; marine-derived fungus; Aspergillus flavus

资金

  1. Korean Government (MOEHRD) [KRF-2008-314-F00048]
  2. [09B2519]

向作者/读者索取更多资源

Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Compounds 1, 2, and 3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The minimum inhibitory concentration (MIC) values for each strain are as follows: compounds 1 and 2 showed 15.6 mu g/ml for S. aureus and 31.2 mu g/ml for methicillin-resistant S. aureus and multidrug-resistant S. aureus, and compound 3 exhibited 31.2 mu g/ml for S. aureus and methicillin-resistant S. aureus and 62.5 mu g/ml for multidrug-resistant S. aureus.

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