期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 59, 期 4, 页码 511-514出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.511
关键词
Ligularia fischeri; sesquiterpenoid; geranylhydroquinone; cytotoxicity; fischerisin A; fischerisin B
资金
- Independent Innovation Foundation of Shandong University, P.R. China [2010ZRYB005]
During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS), 1D- and 2D-NMR data. Fischerisin A and B are the first representatives of a novel sesquiterpenoid-geranylhydroquinone hybrid, and both compounds exhibited in vitro cytotoxicity against cultured human oral epidermoid carcinoma (KB) and human breast cancer (MCF-7) cell lines with IC50 values of 9.7 and 10.2 mu M, and 9.8 and 17.8 mu M, respectively.
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