New Diketopiperazine Derivatives Isolated from Sea Urchin-Derived Bacillus sp.

Two new diketopiperazine derivatives, bacillusamides A (1) and B (2), have been Isolated from the EtOAc extract of the sea urchin-derived Bacillus sp along with the known cyclo(-L-pro-L-val-) (3), cyclo(-L-pro-L-tyr-) (4), cyclo(-L-pro-L-phe-) (5) These structures were elucidated by extensive spectroscopic methods Furthermore, the absolute configurations of the amino acid residues were determined using Marfey's method Compound 1 displayed weak antifungal activity against Aspergillus niger