期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 59, 期 4, 页码 522-524出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.59.522
关键词
vinylogous Mukaiyama aldol reaction; alpha-haloenal; stereoselectivity; cross-coupling
资金
- Japan Society for the Promotion of Science [18390010]
- Grants-in-Aid for Scientific Research [18390010, 22390004] Funding Source: KAKEN
We have developed a high-yielding and stereoselective vinylogous Mukaiyama aldol reaction (VMAR) of alpha-haloenals. Contrary to the simple alpha,beta-unsaturated aldehyde, alpha-haloenals were found to be reactive affording the corresponding VMAR adducts in excellent yields. Some transformations of VMAR adducts by Pd-mediated cross-coupling were also examined in order to demonstrate the synthetic utility of VMAR of alpha-haloenals.
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