期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 58, 期 6, 页码 872-874出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.872
关键词
O-H insertion; enantioselective; rhodium(II); cinchona alkaloid; water
资金
- Academic Frontier Project for Private Universities
- MEXT (Ministry of Education, Culture, Sports, Science and Technology)
Cinchona alkaloids are effective additives for enantioselective O-H insertion of alpha-phenyldiazoacetate and water by rhodium(II) complexes. Addition of silica gel promotes O-H insertion in the reaction rate and the reaction proceeds smoothly at less than the freezing point of water, e.g., -10 degrees C, and provided mandelate in up to 50% ee. The results reported here are the highest asymmetric inductions obtained to date for O-H insertions via a Rh-carbenoid.
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