期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 58, 期 8, 页码 1033-1036出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.58.1033
关键词
endophytic fungus; Penicillium sclerotiorum; azaphilone; antibacterial activity; antifungal activity; anti-human immunodeficiency virus-1 activity
资金
- Commission on Higher Education
- Thailand Research Fund [RTA5180007]
- Development and Promotion of Science and Technology
- Center for Innovation in Chemistry (PERCH-CIC)
- Prince of Songkla University
Two new azaphilone derivatives, penicilazaphilones A (1) and B (2), and one new isocoumarin, penicilisorin (3), together with six known compounds were isolated from the endophytic fungus Penicillium, sclerotiorum PSU-A13. Their structures were identified by analysis of spectroscopic data. The antimicrobial activity against Staphylococcus aureus, Candida albicans and Cryptococcus neoformans as well as the inhibitory effect on human immunodeficiency virus (HIV)-1 integrase and protease were examined.
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