期刊
JOURNAL OF PEDIATRICS
卷 137, 期 3, 页码 374-380出版社
MOSBY-ELSEVIER
DOI: 10.1067/mpd.2000.107891
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Objective: To determine prospectively the relationship among growth, nutritional status, and pulmonary function over a 4-year period in a large cohort of children with cystic fibrosis (CF). Study design: CF Foundation National CF Patient Registry data collected from 1991 to 1995 for 968 children (507 male) aged 5 to 8 years with pancreatic insufficiency and forced expiratory volume in 1 second within 60% to 140% of predicted values (FEV1%) were analyzed longitudinally. Variables hypothesized to affect FEV1% included age, sex, z scores for height, weight; percent of height-appropriate body weight, and annual number of days hospitalized. Results: The significant decline in FEV1% was curvilinear and dependent on baseline FEV1%; children with initial FEV1% greater than or equal to 90 declined 2.6 U/y more than those with initial FEV1% <90. Boys gained but girls declined in z scores for height. Girls decreased in z scores for weight at a greater rate than boys. The z scores for weight and percent of height-appropriate body weight were significantly associated with longitudinal changes in FEV1%, after adjustment was done for hospitalizations. Conclusions: Growth, nutritional status, and pulmonary function are not stable in prepubertal children with CF and pancreatic insufficiency. Important sex-related differences in growth occur before puberty Growth and nutritional status are associated with changes in FEV1%, suggesting that nutritional intervention may slow the decline in pulmonary function in children with CF.
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