期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 57, 期 4, 页码 439-441出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.439
关键词
cannabinoid analog; designer drug; herbal product; (1RS,3SR)-3-[4-(1,1-dimethyloctyl)-2-hydroxyphenyl]cyclohexan-1-ol; drug abuse
资金
- Ministry of Health, Labour and Welfare, Japan
A new type of designer drug, a cannabinoid analog (1), was found in a herbal product distributed on the illegal drug market in Japan in expectation of its narcotic effect. The structure of I was identified by LC-MS, GC-MS, high-resolution MS, and NMR analyses. Compound I showed a molecular weight of 332, and accurate mass measurement exhibited its elemental composition to be C22H36O2. Together, the mass and NMR spectrometric data revealed that 1 was (1RS,3SR)-3-[4-(1,1-dimethyloctyl)-2-hydroxyphenyl]cyclohexan-1-ol, which was first synthesized in 1979 by a group at Pfizer Inc. and reported as a potent cannabinoid analog possessing cannabinoid receptor binding activity and analgesic activity in the 1990s. This is the first report to identify a cannabinoid analog in an illegal drug.
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