期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 57, 期 10, 页码 1089-1095出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.57.1089
关键词
Cissus sicyoides; flavonoid; benzofuran-type stilbene; cissoside; cissusin; degranulation inhibitor
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
Three new flavonoid glycosides (cissosides I, II, and III) and a new benzofuran-type stilbene (cissusin) were isolated from the methanolic extract of the aerial parts of Cissus sicyoides cultivated in Brazil. Their structures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated constituents on the release of beta-hexosaminidase as a marker of degranulation in rat basophilic leukemia (RBL-2H3) cells were examined. Cissusin, flavonols (kaempferol, quercetin), flavones (7,3',4'-trihydroxyflavone, lanceolatin B), pterocarpanes (homopterocarpin), chalcones (isoliquiritigenin, E-7-O-methylpongamol), and tryptanthrin markedly inhibited the release of beta-hexosaminidase.
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