期刊
AMERICAN JOURNAL OF PATHOLOGY
卷 156, 期 3, 页码 889-898出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0002-9440(10)64958-9
关键词
-
类别
资金
- NCI NIH HHS [CA 77386] Funding Source: Medline
- NIDDK NIH HHS [DK 55686, R37 DK047556, R01 DK047556, R01 DK055686, DK 47556] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA077386] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK055686, R37DK047556, R01DK047556] Funding Source: NIH RePORTER
The expression of certain growth factors in the epidermal growth factor (EGF) family is altered in response to renal injury. Recent studies have demonstrated that heparin binding EGF-like growth factor (HB-EGF) expression may be cytoprotective in response to apoptotic signals. The purpose of this study was to investigate the potential role of HB-EGF in the upper urinary tract following unilateral ureteral obstruction. We present evidence that: i) ureteral obstruction induced cell-specific but transient activation of HB-EGF gene expression; ii) HB-EGF expression in renal epithelial cells increased under conditions where mechanical deformation, such as that caused by hydronephrotic distension, induces apoptosis,but HB-EGF expression did not increase in renal pelvis smooth muscle cells under identical conditions; and iii) enforced expression of HB-EGF served to protect renal epithelial cells from stretch-induced apoptosis. These results suggest a potential mechanism by which the kidney protects itself from apoptosis triggered by urinary tract obstruction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据