期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 56, 期 10, 页码 1400-1405出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.56.1400
关键词
SARS coronavirus 3CL protease; cinanserin analogs; inhibitor; fluorescence resonance energy transfer-based assay
The severe acute respiratory syndrome (SARS) coronavirus 3CL protease is an attractive target for the development of anti-SARS drugs. In this paper, cinanserin (1) analogs were synthesized and tested for the in-hibitory activities against SARS-coronavirus (CoV) 3CL protease by fluorescence resonance energy transfer (FRET) assay. Four analogs show significant activities, especially compound 26 with an IC50 of 1.06 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据