期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 71, 期 3, 页码 752-756出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/71.3.752
关键词
Prader-Willi syndrome; obesity; child; energy metabolism; body composition; bone age; fat-free mass; basal metabolic rate; sleeping metabolic rate
Background: Obesity in Prader-Willi syndrome (PWS) seems to be related to a low basal metabolic rate (BMR). In addition, abnormal sleep patterns reported in PWS might affect sleeping metabolic rare (SMR). Objective: Our objective was to assess BMR and SMR adjusted for fat-free mass in young PWS patients. Design: Subjects were 17 PWS patients (10 females and 7 males aged 7.5-19.8 y) and 17 obese control subjects matched for sex and bone age. SMR was measured in a respiratory chamber, BMR with a ventilated-hood system, and body composition by deuterium dilution. Results: BMR and SMR were significantly lower in the PWS group than in the control group (5.36 +/- 1.18 and 4.62 +/- 1.08 MJ/d compared with 6.38 +/- 1.55 and 5.60 +/- 1.52 MJ/d, respectively; P < 0.05). When fat-free mass was included in the analysis, multiple regression showed no differences in BMR and SMR between groups. When weight was included in the analysis instead of fat-free mass, SMR was lower in the PWS group. Fat-free mass was lower in the PWS group both as an absolute value and when adjusted for height. Conclusion: BMR and SMR are low in young patients with PWS because of a low fat-free mass.
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