期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 45, 期 1, 页码 9-13出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/45.1.9
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Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.
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