[I-123]FP-CIT binding in rat brain after acute and sub-chronic administration of dopaminergic medication

The recently developed radioligand [I-123]FP-CIT is suitable for clinical single-photon emission tomography (SPET) imaging of the dopamine (DA) transporter in vivo. To date it has remained unclear whether dopaminergic medication influences the striatal [I-123]FP-CIT binding. The purpose of this study was to investigate the influence of this medication on [I-123]FP-CIT binding in the brain. We used an animal model in which we administered dopaminomimetics, antipsychotics and an antidepressant. In vivo [I-123]FP-CIT binding to the DA and serotonin transporters was evaluated after subchronic and acute administration of the drugs. The administered medication induced small changes in striatal [I-123]FP-CIT binding which were not statistically significant. As expected, the DA reuptake blocker GBR 12,909 induced a significant decrease in [I-123]FP-CIT binding. [I-123]FP-CIT binding in the serotonin-rich hypothalamus was decreased only after acute administration of fluvoxamine, The results of this study suggest that dopaminergic medication will not affect the results of DA transporter SPET imaging with [I-123]FP-CIT.