期刊
RADIATION PHYSICS AND CHEMISTRY
卷 57, 期 3-6, 页码 481-484出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0969-806X(99)00476-4
关键词
PVA-g-NIPAAm; thermo-response hydrogel; radiation grafting; controlled release
Thermosensitive PVA-g-NIPAAm copolymers were prepared by graft copolymerization of N-isopropylacrylamide (NIPAAm) onto poly (vinyl alcohol) (PVA) in homogeneous system of dimethyl sulfoxide (DMSO) by Co-60-gamma irradiation at room temperature. The factors of affecting the grafting yield, such as radiation dose, dose rate, acid concentration, were investigated. It was found that the grafting yield was increased with dose up to 30 kGy, but decreased slightly with dose rate from 61.2 to 50.1 Gy/min. The acid concentration also had influence on the grafting yield. Then the hydrogel of PVA-g-NIPAAm copolymer was made through a freezing-thawing process. The PVA-g-NIPAAm hydrogel exhibited obvious thermal sensitivity, which was observed from the differences of swelling behavior in water at different temperatures (below or above LCST). In addition, the release of Methylene Blue (MB) from this kind of hydrogel was studied. The release rate of MB from PVA-g-NIPAAm copolymer hydrogel at 48 degrees C was faster than that at 15 degrees C due to the shrinkage of the hydrogel at 48 degrees C. (C) 2000 Elsevier Science Ltd. All rights reserved.
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