期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 67, 期 1, 页码 104-108出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1002/jlb.67.1.104
关键词
lamp proteins; macrophage scavenger receptors; endosomal membrane proteins
Macrosialin, the mouse homolog of human CD68, is a heavily glycosylated transmembrane protein found almost exclusively in macrophages. Its function remains uncertain. If has a high affinity for oxidized low-density lipoprotein (LDL) in Ligand blots and antibodies against the human homolog, CD68, inhibit the binding of oxidized LDL to a human monocyte-derived cell line (THP-1), However, there is still controversy as to whether macrosialin, found predominantly in late endosomes, is expressed at all on the plasma membrane, The present studies, done in thioglycollate-elicited peritoneal macrophages, confirm that macrosialin is predominantly intracellular but show clearly that 10-15% of it is expressed on the cell surface. Exchange with intracellular pools occurs at an extremely high rate, The results are compatible with a surface function, including internalization of hound ligands or adhesion to surfaces.
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