期刊
VISION RESEARCH
卷 40, 期 4, 页码 371-381出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0042-6989(99)00184-4
关键词
myopia; diffuser lens; monkey; emmetropization; defocus
资金
- NEI NIH HHS [EY 03611, P30 EY007551, EY 07551] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY003611, P30EY007551] Funding Source: NIH RePORTER
To shed light on the potential role of the phenomenon of form-deprivation myopia in normal refractive development, we investigated the degree of image degradation required to produce axial myopia in rhesus monkeys. Starting at about 3 weeks of age, diffuser spectacle lenses were employed to degrade the retinal image in one eye of 13 infant monkeys. The diffusers were worn continuously for periods ranging between 11 and 19 weeks. The effects of three different strengths of optical diffusers, which produced reductions in image contrast that ranged from about 0.5 to nearly 3 log units, were assessed by retinoscopy and A-scan ultrasonography. Control data were obtained from ten normal infants and three infants reared with clear, zero-powered lenses over both eyes. Eleven of the 13 treated infants developed form-deprivation myopia. Qualitatively similar results were obtained for the three diffuser groups, however, the degree of axial myopia varied directly with the degree of image degradation. Thus, form-deprivation myopia in monkeys is a graded phenomenon and can be triggered by a modest degree of chronic image degradation. (C) 1999 Elsevier Science Ltd. All rights reserved.
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