期刊
NATURE CELL BIOLOGY
卷 2, 期 9, 页码 666-668出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/35023621
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资金
- NATIONAL CANCER INSTITUTE [R01CA055833] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL033009] Funding Source: NIH RePORTER
- NCI NIH HHS [CA55833] Funding Source: Medline
- NHLBI NIH HHS [HL33009] Funding Source: Medline
- NIDCR NIH HHS [DE00275] Funding Source: Medline
This study was carried out to discriminate between two alternative hypotheses as to how cells sense mechanical forces and transduce them into changes in gene transcription. Do cells sense mechanical signals through generalized membrane distortion(1,2) or through specific transmembrane receptors, such as integrins(3)? Here we show that mechanical stresses applied to the cell surface alter the cyclic AMP signalling cascade and downstream gene transcription by modulating local release of signals generated by activated integrin receptors in a G-protein-dependent manner, whereas distortion of integrins in the absence of receptor occupancy has no effect.
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