期刊
PEPTIDES
卷 21, 期 9, 页码 1361-1367出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(00)00279-5
关键词
insulin; dopamine; rats; food intake; reward
资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK040963] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [T32NS007431] Funding Source: NIH RePORTER
- NIDDK NIH HHS [DK40963] Funding Source: Medline
- NINDS NIH HHS [T32 NS007431] Funding Source: Medline
We have previously reported that the hormone insulin can modulate synaptic function of dopamine neurons. To evaluate whether insulin can alter performance of a task which is dependent on intact dopaminergic signaling, we tested rats in a five minute lick rate task, with a range of concentrations of sucrose or oil solutions. Rats received either ip (t - 15 min) saline or the D2 receptor antagonist raclopride (50 mug/kg), and intraventricular (t - 4 h) saline or insulin (5 mU). Although ineffective on its own, insulin combined with raclopride treatment resulted in significant suppression of sucrose lick rates compared to the saline/saline group. The overall results are consistent with our hypothesis that insulin may modify performance in tasks that are dependent on dopaminergic signaling. (C) 2000 Elsevier Science Inc. All rights reserved.
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