期刊
BRAIN AND COGNITION
卷 42, 期 2, 页码 268-293出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/brcg.1999.1104
关键词
electrical stimulation; cognition; Parkinson's disease; thalamus; globus pallidus; subthalamus
Modem ablative surgery for movement disorders probably results in less frequent and severe cognitive morbidity than seen in early surgical series. Nonetheless, recent studies indicate that neurobehavioral functions commonly compromised in Parkinson's disease (PD) (e.g., executive functions, verbal fluency and memory) are negatively impacted in some patients by lesion placement. The potential reversibility of cognitive dysfunction after chronic electrical deep brain stimulation (DBS) for PD has lead some to favor this treatment modality over ablation. This paper reviews the initial studies of the cognitive effects of thalamic, pallidal, and subthalamic DBS. These studies suggest that DBS is relatively safe from a cognitive standpoint and that the benefits of motor improvements probably outweigh the cost of minimal cognitive morbidity. This conclusion must be offered with caution, however, given the small numbers of studies to date and their methodological limitations. Neurobehavioral research has vet to adequately address (1) outcome relative to appropriate control groups; (2) effects of electrode placement venus stimulation: (3) laterality- and site-specific effects of DBS: (4) long-term effects: of DBS: (5) effects of stimulation parameters: (6) risk factors for cognitive dysfunction with DBS; (7) whether cognitive dysfunction associated with DBS is reversible; and (8) comparative neurobehavioral outcome after DBS and ablation. DBS affords an exciting opportunity to clarify the neurobehavioral role of the basal ganglia. (C) 2000 Academic Press.
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