期刊
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
卷 108, 期 3, 页码 293-309出版社
SWETS ZEITLINGER PUBLISHERS
DOI: 10.1076/1381345520000710831ZFT293
关键词
cat; morphometry; motoneuron; neuron death; quantitative analysis; regeneration
This study assesses qualitative and quantitative morphological changes that occur in motoneurons after ventral root avulsion. The motoneuronal perikaryal changes in the ventral horn of the cat's C7 cord segment were studied after survival times of 2, 8, 14, 30, 60 and 90 days. Generally, large motoneurons showed a light type of reaction, and the small ones either light or dark. In addition, neurons with a normal ultrastructural appearance were found. These latter are considered to be in a 'steady state', which may be associated with regenerative potency. All these types of neuron reactions were present at all survival times, but the number of cells marked by a specific reaction depends on the time of survival. Qualitative and quantitative evidence is given for cell death in 36% of the motoneuronal population between 2 and 14 days after avulsion. This reduction primarily concerns large, presumably motoneurons with the light type reaction. Small, presumably motoneurons become seriously affected after 14 days. These findings suggest that early surgical repair may have the better chances for clinical recovery.
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