期刊
NATURE CELL BIOLOGY
卷 2, 期 1, 页码 13-19出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/71330
关键词
-
类别
资金
- NIGMS NIH HHS [R01 GM059618] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM059618] Funding Source: NIH RePORTER
Microtubules are dynamic polymers that move stochastically between periods of growth and shrinkage, a property known as dynamic instability, Here, to investigate the mechanisms regulating microtubule dynamics in Xenopus egg extracts, we have cloned the complementary DNA encoding the microtubule-associated protein XMAP215 and investigated the function of the XMAP215 protein. Immunodepletion of XMAP215 indicated that it is a major microtubule-stabilizing factor in Xenopus egg extracts. During interphase, XMAP215 stabilizes microtubules primarily by opposing the activity of the destabilizing factor XKCM1, a member of the kinesin superfamily. These results indicate that microtubule dynamics in Xenopus egg extracts are regulated by a balance between a stabilizing factor, XMAP215, and a destabilizing factor, XKCM1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据