期刊
NEUROPHARMACOLOGY
卷 39, 期 12, 页码 2346-2351出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0028-3908(00)00064-2
关键词
serotonin; frontal cortex; alcohol; patch clamp
资金
- NIAAA NIH HHS [AA00176, AA08986] Funding Source: Medline
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R37AA008986, R01AA008986] Funding Source: NIH RePORTER
The function of 5-hydroxytryptamine (5-HT)(3) receptors was examined by whole-cell patch-clamp recording in dissociated frontal cortex neurons from 5-HT3 receptor overexpressing transgenic, and wild-type mice. The effect of acute exposure to alcohols on the 5-HT3 receptor-mediated ion current was also investigated. The 5-HT3 receptors expressed on frontal cortex neurons in transgenic mice were activated by 5-HT and a selective 5-HT3 receptor agonist, 2-methyl-5-HT. This current was blocked by zacopride, a specific 5-HT3 receptor antagonist. Dissociated frontal cortex neurons from wild-type mice exhibited little or no 5-HT3 receptor-mediated current. Ethanol (EtOH) and trichloroethanol (TCEt) potentiated the function of 5-HT3 receptors overexpressed in transgenic mice. This is the first evidence that 5-HT3 receptors exhibit sensitivity to alcohols when expressed by a central neuron. (C) 2000 Elsevier Science Ltd. All rights reserved.
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