期刊
ACTA NEUROPATHOLOGICA
卷 100, 期 3, 页码 270-274出版社
SPRINGER VERLAG
DOI: 10.1007/s004010000182
关键词
ballooned neuron; Golgi apparatus; corticobasal degeneration; Creutzfeldt-Jakob disease
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS036732] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS36732] Funding Source: Medline
We investigated immunohistologically the Golgi apparatus (GA) and the trans-Golgi network (TGN) of the cortical ballooned neurons (BNs) in two patients with corticobasal degeneration and in five with Creutzfeldt-Jakob disease. We observed that the BNs showed fragmentation of the GA and the TGN, accompanied by a reduction in the number of fragmented Golgi elements and by a unique perinuclear distribution. This is the first report of the abnormalities of GA in cortical BNs. These findings suggests that the GA and the TGN may play some roles in the BN formation.
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