期刊
LIPIDS
卷 35, 期 9, 页码 967-974出版社
AMER OIL CHEMISTS SOC A O C S PRESS
DOI: 10.1007/s11745-000-0607-x
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Oxidative stress is believed to play an important role in the pathophysiology of asthma. Recently discovered F2-isoprostanes, of which 8-iso-PGF(2 alpha) is the most well-known isomer, have emerged as the most reliable marker of in vivo oxidative stress. The aim of this study was to examine 8-iso-PGF(2 alpha) as a biomarker of oxidative stress in mild asthma in relation to endogenous and dietary antioxidant protection. Total (free and esterified) plasma 8-iso-PGF(2 alpha') plasma dietary antioxidants (vitamins E and C, beta-carotene, Zn, and Se), and erythrocyte antioxidant enzyme activities (glutathione peroxidase and superoxide dismutase) were measured in 15 mild asthmatics and 15 age- and sex-matched controls. Total plasma 8-iso-PGF(2 alpha) levels [median (quartile 1 - quartile 3)] were significantly increased in the asthmatics [213 pg/mL (122-455) vs. 139 pg/mL (109-174), P = 0.042]. The 8-iso-PGF(2 alpha) levels were found to be associated with clinical asthma severity (P = 0.044) and inhaled corticosteroid use(P= 0.027) in asthmatics. No differences were observed in the plasma dietary antioxidant vitamins. The asthmatics had significantly lower plasma levels of Zn (P = 0.027) and Se (P = 0.006). Plasma Se correlated negatively with 8-iso-PGF(2 alpha) (r = -0.725, P= 0.002). No differences between the groups were observed for glutathione peroxidase or superoxide dismutase, however, superoxide dismutase activity was negatively associated with asthma severity(P= 0.042). In conclusion, oxidative stress is increased in mild asthmatics, as reflected by increased plasma levels of 8-iso-PGF(2 alpha) and a deficiency in plasma Zn and Se. The isoprostane 8-iso-PGF(2 alpha) may provide a useful tool in intervention studies aimed at improving clinical status in asthma.
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