期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 55, 期 3, 页码 B117-B123出版社
GERONTOLOGICAL SOCIETY AMER
DOI: 10.1093/gerona/55.3.B117
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资金
- NIA NIH HHS [P30 AG013283, AG08808, AG13283, P60 AG008808] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [P30AG008808, P60AG008808, P30AG013283] Funding Source: NIH RePORTER
This essay presents some practical advice and suggestions for those who wish to use mice and rats in experiments on the biology of aging. Ten principles set forth guidance on choice of ages, choice of stocks, the importance of specific pathogen-free status, the uses of necropsy data, the dangers of pooling samples from different individuals, planning ahead for loss of aged mice to death and disease, the use of cost-adjusted power calculations, and the dangers of inferring causal associations from correlated age effects.
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