期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 26, 期 7, 页码 773-776出版社
MARCEL DEKKER INC
DOI: 10.1081/DDC-100101297
关键词
chloroquine phosphate; drug release; ion-exchange resin; stability; taste masking
High-potency adsorbates of chloroquine phosphate (CQP) were prepared by the batch method using a polyacrylic acid ion-exchange resin. Taste evaluation of the adsorbates shows significant masking of the bitterness of the drug. The complex formation was complete at pH 6.0. Stability studies at 37 degrees C, 45 degrees C,and 60 degrees C indicated that the complex was stable at all conditions for 1 month. In vitro release studies revealed complete drug elution from the complex at pH 1.2 and 2.0.
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