期刊
ACS CHEMICAL NEUROSCIENCE
卷 6, 期 8, 页码 1296-1301出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.5b00116
关键词
Blood-brain barrier; shock wave; cavitation effect; traumatic brain injury; claudin protein; tight junction
资金
- Office of Naval Research [N00014-14-1-0241]
Passage of a shock wave across living organisms may produce bubbles in the blood vessels and capillaries. It was suggested that collapse of these bubbles imposed by an impinging shock wave can be responsible for the damage or even destruction of the blood-brain barrier. To check this possibility, we performed molecular dynamics computer simulations on systems that contained a model of tight junction from the blood-brain barrier. In our model, we represent the tight junction by two pairs of interacting proteins, claudin-15. Some of the simulations were done in the absence of a nanobubble, some in its presence. Our simulations show that when no bubble is present in the system, no damage to tight junction is observed when the shock wave propagates across it. In the presence of a nanobubble, even when the impulse of the shock wave is relatively low, the implosion of the bubble causes serious damage to our model tight junction.
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