期刊
NEUROPSYCHOLOGIA
卷 38, 期 9, 页码 1292-1304出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0028-3932(00)00026-9
关键词
functional MRI; verbal response initiation; response suppression; inhibition; strategy use; prefrontal cortex
Cerebral activation associated with performance on a novel task involving two conditions was investigated with functional magnetic resonance imaging (fMRI), In the response initiation condition, subjects nominated the general subordinate category to which each of a series of exemplars (concrete nouns) belonged. In the response suppression condition, subjects were required to nominate a general superordinate category Co which each exemplar did not belong, with the instruction that they a ere not to nominate the same category response twice in a row. Both conditions produced distinct patterns of activation relative to an articulation control condition employing identical stimuli. When initiation and suppression conditions were directly compared, response suppression produced activation in the right frontal pole, orbital frontal cortex and anterior cingulate, left dorsolateral prefrontal cortex and posterior cingulate, and bilaterally in the precuneus, visual association cortex and cerebellum Response latencies were significantly longer in the suppression condition. Two broadly-defined strategies associated with the comet production of words during the suppression condition were a self-ordered selection from among the superordinate categories identified during the first section of the task and the generation of novel category responses. The neuroanatomical correlates of response initiation, suppression and strategy use are discussed, as are the respective roles of response suppression and strategy generation. (C) 2000 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据