期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 20, 期 1, 页码 21-27出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004647-200001000-00005
关键词
diffusion; perfusion; magnetic resonance imaging; thrombolysis; therapeutic window; cerebral ischemia
资金
- NINDS NIH HHS [R01 NS33627, R01 NS38292, P01 NS23393] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS023393, R01NS038292, R01NS033627] Funding Source: NIH RePORTER
With use of magnetic resonance imaging (MRI), the effects of early and delayed treatment of embolic stroke in rat with recombinant tissue plasminogen activator (rt-PA) were investigated. Rats with embolic stroke were treated with rt-PA at 1 (n = 9) or 4 (n = 7) hours after stroke onset or were untreated (n = 15). Diffusion-weighted imaging, perfusion-weighted imaging, and T2-weighted imaging were performed before and after embolization from 1 hour to 7 days. No significant differences were detected in the relative areas with low cerebral blood flow (CBF), apparent diffusion coefficient of water (ADC(w)), and T2 between the 4-hour treated group and the untreated group. Significant decreases in the average relative areas with low CBF were detected in the I-hour treated group from 4 to 48 hours after embolization as compared with the untreated group. The increase in T2 in the 1-hour treated group was significantly lower than in the untreated and 4-hour treated groups. A significant increase in ADC, was detected in the 1-hour treated group at 3 and 24 hours after embolization as compared with the untreated and 4-hour treated groups. Secondary embolization was detected by both MRI and laser scanning confocal microscopy. The data suggest that MRI can detect the efficacy of rt-PA treatment and secondary ischemic damage.
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