期刊
JOURNAL OF CLINICAL GASTROENTEROLOGY
卷 30, 期 1, 页码 29-33出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004836-200001000-00006
关键词
cobalamin; omeprazole; lansoprazole; absorption
Reduced serum vitamin B-12 (cobalamin) levels have been documented occasionally during long-term treatment with a proton pump inhibitor (PPI) in selected groups of patients. This has largely been confined to patients being treated for Zollinger-Ellison syndrome who have sustained drug-induced achlorhydria, which does not ordinarily occur during treatment with a PPI. An appreciation of normal cobalamin metabolism and the pharmacological action of the PPIs adequately explain the mechanism for this reduction. PPIs do not promote the development of pernicious anemia.
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