期刊
PEDIATRIC NEUROLOGY
卷 23, 期 3, 页码 274-277出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0887-8994(00)00183-1
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We determined that zonisamide was effective in three epileptic infants with hypsarrhythmia. Two patients had the electroencephalographic pattern of hypsarrhythmia associated with developmental delay but lacked the characteristic tonic spasms. A third patient exhibited the typical triad of infantile spasms but had a poor general condition requiring controlled ventilation. We therefore chose zonisamide instead of adrenocorticotropin for these patients. Our data suggest that zonisamide may be a useful treatment in patients falling short of the diagnostic triad of infantile spasms or complicated by a poor overall medical condition. (C) 2000 by Elsevier Science Inc. All rights reserved.
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