4.6 Article

Conserved noncoding sequences are reliable guides to regulatory elements

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TRENDS IN GENETICS
卷 16, 期 9, 页码 369-372

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ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(00)02081-3

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  1. NIDDK NIH HHS [DK27635] Funding Source: Medline
  2. NLM NIH HHS [LM05110, LM05773] Funding Source: Medline
  3. NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK027635] Funding Source: NIH RePORTER
  4. NATIONAL LIBRARY OF MEDICINE [R01LM005773, R01LM005110] Funding Source: NIH RePORTER

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A 'working draft' of the human genome sequence is now available. Comparisons with the sequences of mouse and other species will be a powerful approach to identifying functional segments of the noncoding regions, such as gene regulatory elements. However, the choice of a species for most effective comparison differs among various loci.

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