期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 25, 期 9, 页码 414-418出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01623-6
关键词
-
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM029009] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM-29009] Funding Source: Medline
Mismatch repair in many organisms depends on three proteins: the mismatch-recognition protein MutS, a nicking endonuclease MutH, and MutL, which acts as a scaffold between these. However, many genomes lack MutL but possess MutS. In one of these cases, in a coral mitochondrial genome, a gene is present that encodes a MutS protein fused to an HNH nicking endonuclease, potentially eliminating the requirement for MutL, Likewise, many prokaryotes could operate similarly, independently of MutL by encoding a fused MutS-Smr (MutS2) protein. Smr, which is proposed to be a nicking endonuclease, can also be found separately in many eukaryotes, where it might play a role in mismatch repair or meiotic chromosome crossing-over.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据