Nuclear hormone receptors and mouse skin homeostasis: Implication of PPAR beta

PPAR beta is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPAR beta heterozygous mice reveal that PPAR beta is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound. Copyright (C) 2001 S. Karger AG, Basel.