期刊
IMMUNITY
卷 12, 期 1, 页码 39-49出版社
CELL PRESS
DOI: 10.1016/S1074-7613(00)80157-0
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资金
- NCI NIH HHS [CA13148] Funding Source: Medline
- NIAID NIH HHS [AI 14782, R01 AI014782] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA013148] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI014782, R01AI014782] Funding Source: NIH RePORTER
Using immunoglobulin heavy chain transgenic mice, we show that B cell clones reaching the long-lived pool are heterogeneous: some are enriched in the CD21(high) compartment (mostly marginal zone [MZ]), others reside primarily in the follicles (FO). Altering the composition of the B cell receptor through N region additions decreases the rate of clonal production and the MZ enrichment. This process can be recapitulated by purified CD21(low) B cells and is due to a preferential clonal survival that requires a functional btk tyrosine kinase, We also show that generation of the MZ population is dependent on CD19. These findings suggest that the MZ B cell repertoire is positively selected and have functional implications for antigenic responses effected by B cells from this microenvironment.
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