期刊
FREE RADICAL RESEARCH
卷 33, 期 3, 页码 197-+出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760000301381
关键词
LDL; oxidative stress; exercise; estradiol; antioxidant
资金
- NHLBI NIH HHS [HL 52628-01A3] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL052628] Funding Source: NIH RePORTER
The atherogenic oxidative modification of low-density lipoprotein is suggested to occur in the aortic intima. There is reasonable evidence to suggest that antioxidants might be beneficial in preventing or retarding the progression of atherosclerosis, Exercise, estrogens, and substitution of polyunsaturated fat for saturated fat are beneficial in the prevention of atherosclerosis. Yet, paradoxically, they are capable of inducing an oxidative stress. To reconcile with this paradox, we postulate that under certain conditions an oxidative stress might be beneficial by inducing antioxidant enzymes in arterial cells. However, those with genetic deficiency in antioxidant enzymes or those who poorly respond to oxidative stress or those with overwhelming plasma oxidative stress might need additional antioxidant protection.
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