期刊
ANNALS OF BIOMEDICAL ENGINEERING
卷 28, 期 1, 页码 26-38出版社
AMER INST PHYSICS
DOI: 10.1114/1.251
关键词
coronary artery; oxygen; atherosclerosis; mass flux; shear stress
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL035549] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL 35549] Funding Source: Medline
Arterial wall transport of blood-borne oxygen is essential for superficial arterial wall metabolism. The unique geometry and hemodynamics of coronary arteries curved over the heart surface may alter the O-2 transport pattern and lead to abnormalities of O-2 tension at the inner wall (epicardial surface) which may contribute to atherogenesis. This study focused on O-2 transport in a compliant model of a curved coronary artery. A three-dimensional finite element model with moving boundaries was setup to simulate physiological how and O-2 transport in coronary arteries. The full Navier-Stokes equations and the coupled conservation of species equation were solved simultaneously for typical coronary flow characteristics (aspect ratio=10, diameter variation=6%, mean Reynolds number=150, unsteadiness parameter=3, Schmidt number=2700). The results indicate a large difference in O-2 wall flux (Sherwood number [Sh]) between the outside (Sh about 55) and inside (Sh about 2) walls and imply that O-2 transport at the inner wall could be limited by the fluid phase. (C) 2000 Biomedical Engineering Society. [S0090-6964(oo)01101-2].
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