期刊
LUPUS
卷 9, 期 5, 页码 374-376出版社
SAGE PUBLICATIONS LTD
DOI: 10.1191/096120300678828451
关键词
anti-ENA; systemic lupus erythematosus; ethnic group
类别
Objective: To assess how anti-ENA characteristics change in patients with systemic lupus erythematosus from different ethnic backgrounds over a 10-year period follow-up study. Results: There were 61 patients, of whom 37 were Caucasian, 12 were Asian and 12 were Afro-Caribbean At the first available bleed 12/37 (32%) Caucasians were anti-ENA positive compared to 6/12 (50%) Asians and 9/12 (75%) of Afro-Caribbeans (Chi-squared P = 0.01 for Caucasian vs Afro-Caribbean) and these proportions remained essentially unchanged after 10 y of follow-up. However, over the 10 y of follow-up anti-ENA patterns did change, with anti-so being the commonest antibody pattern to emerge and anti-Ro/La the commonest antibody pattern to disappear. There were 20/37(54%) Caucasians, 1/12(8%) Afro-Caribbeans and 5/12(42%) Asians who remained negative for anti ENA throughout the 10-year follow-up (Chi-squared P = 0.03 for Caucasian vs Afro-Caribbean). Conclusion: Anti-ENA were more commonly found in the Afro-Caribbean than the Caucasian population. The commonest patterns of anti-ENA differ between ethnic groups and, over a 10-year period, anti-ENA patterns in individual patients changed in a significant number of individuals. However. Caucasians were more likely to remain anti-ENA negative over 10 y of follow-up than Afro-Caribbeans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据