期刊
LUPUS
卷 9, 期 2, 页码 101-109出版社
STOCKTON PRESS
DOI: 10.1191/096120300678828046
关键词
SLE; fatigue; disease activity
类别
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR002558, M01RR000073] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR042503] Funding Source: NIH RePORTER
- NCRR NIH HHS [M01-RR00073, M01-RR02558] Funding Source: Medline
- NIAMS NIH HHS [R01-AR42503] Funding Source: Medline
Objective: To determine the frequency, degree and associated features of fatigue among Hispanic (H), African American (AA) and Caucasian (C) patients with recent onset (less than or equal to 5 yr) systemic lupus erythematosus (SLE) at their baseline evaluation. Methods: H (n = 69), AA (n = 83) acid C (n = 71) patients from the LUMINA (LUpus in MInority populations: NAture vs Nurture) cohort were studied. Fatigue [Fatigue Severity Scale (FSS)] was defined as present if FSS score greater than or equal to 3.0. Variables from functional, clinical, sociodemographic, health behaviors, behavioral and psychological and immunogenetics domains were ascertained at study entry. Associations were examined using regression models. Results: Eighty-six percent (85.7%) of patients reported having fatigue (82.6% H; 85.5% AA; 88.7% C); median FSS score, 5.3. Factors from the psychological and clinical domains were primarily associated with FSS; immunogenetic (HLA Class II phenotypes) features were not. Increased fatigue was strongly associated with decreasing function, both physical and mental. Variables associated with significantly greater degree of fatigue at baseline in the multivariable stepwise model in order of decreasing additional partial R-2 explained included: abnormal illness-related behaviors, older age, higher self-reported pain, greater degree of helplessness, greater disease activity, Caucasian race, and lacking health insurance (model R-2 = 37%). Conclusions: Fatigue is one of the most prevalent clinical manifestations of SLE across all ethnic groups. The perception of fatigue severity in SLE may be multifactorial in origin, including psychosocial factors and disease activity. If these prove causal, knowledge of their contribution may suggest therapeutic and/or behavioral interventions, which could ameliorate this pervasive and often incapacitating symptom of SLE.
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