期刊
PROTOPLASMA
卷 217, 期 1-3, 页码 33-36出版社
SPRINGER-VERLAG WIEN
DOI: 10.1007/BF01289410
关键词
oxidative stress; hydroxyl radical; superoxide dismutase
Superoxide is considered to be poorly reactive, and cell damage has been attributed to HO. generated via the Haber-Weiss reaction. The function of O-2(-). in this reaction is only to reduce Fe3+ to Fe2+. In vivo, however, superoxide could not out-compete cellular reductants such as glutathione, NADPH, and ascorbate, which makes the observed O-2(-) toxicity rather puzzling. Little attention has been paid to the idea that, irrespective of its poor chemical reactivity, superoxide might be capable of interacting directly with specific intracellular targets; and that even the Haber-Weiss reaction might be a consequence of such direct interactions. This paper summarizes latest data that support the concept of such a mechanism.
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