期刊
CHEMISTRY & BIOLOGY
卷 8, 期 1, 页码 1-7出版社
CELL PRESS
DOI: 10.1016/S1074-5521(00)00058-2
关键词
DNA recognition; locked nucleic acid; gene expression control; RNA recognition
资金
- NIGMS NIH HHS [R01GM 60624] Funding Source: Medline
Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and the 4'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays. (C) 2001 Elsevier Science Ltd. All rights reserved.
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