Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA

Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and the 4'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays. (C) 2001 Elsevier Science Ltd. All rights reserved.