期刊
BIOLOGY OF THE NEONATE
卷 79, 期 1, 页码 54-60出版社
KARGER
DOI: 10.1159/000047066
关键词
glutamine; glutamate; fetal liver; parturition; placenta; amino acid exchange
类别
资金
- NICHD NIH HHS [R01 HD29374, P50HD20761] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P50HD020761, R01HD029374] Funding Source: NIH RePORTER
The uptake and/or release of amino acids across the feta I liver and the placenta were studied in 8 pregnant sheep during the 5 days preceding delivery of the lamb. During spontaneous parturition, there was a significant decrease in fetal hepatic glutamine uptake, in fetal hepatic glutamate release and in placental glutamate uptake. The fetal plasma concentrations of glutamate, leucine, isoleucine, valine, phenylalanine, serine and tyrosine also decreased significantly in the 5 days preceding delivery. There was no significant net output of glucose from the fetal liver nor any change in net lactate uptake by the liver. During this same time period there was a significant increase in the fetal plasma cortisol concentration and a decrease in progesterone output by the pregnant uterus. The results are compared to the previously reported amino acid changes during dexamethasone-induced parturition. Copyright (C) 2001 S. Karger AG, Basel.
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