4.4 Review

Regulation of receptor tyrosine kinase signaling by endocytic trafficking

期刊

TRAFFIC
卷 2, 期 1, 页码 12-18

出版社

MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1600-0854.2001.020103.x

关键词

EGFR; endosome; insulin receptor; TrkA; tyrosine kinase; ubiquitin

资金

  1. NICHD NIH HHS [P01-HD28528] Funding Source: Medline
  2. EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [P01HD028528] Funding Source: NIH RePORTER

向作者/读者索取更多资源

Activated receptor tyrosine kinase (RTK) receptors are rapidly internalized and eventually delivered to the lysosomes. Although ligand-induced endocytosis was originally thought to be a mechanism of receptor inactivation, many studies suggest that receptors remain active within endosomes. This review discusses the role that internalized signaling complexes may play in different RTK systems including recent data on how ubiquitination may regulate this process. In general, it appears that some receptor systems have evolved to enhance endosomal signaling, as is the case for TrkA and NGF. In contrast, the insulin receptor system appears to limit the extent of endosomal signaling. The EGFR system is the intermediate example. In this case, some signals are specifically generated from the cell surface while others appear to be generated from within endosomes. This may act as a mechanism to produce ligand-specific signals. Thus, trafficking could play diverse roles in receptor signaling, depending on the specific cell and tissue type.

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